abstract：:Peroxisome proliferator-activated receptor γ (PPARγ) is a versatile member of the ligand-activated nuclear hormone receptor superfamily of transcription factors, with expression in several different cell lines, especially in the digestive system. After being activated by its ligand, PPARγ can suppress the growth of or...

journal_title：Current stem cell research & therapy

authors： Shu L,Huang R,Wu S,Chen Z,Sun K,Jiang Y,Cai X

更新日期：2016-01-01 00:00:00

abstract：:Stroke is the second most common cause of death and the leading cause of disability in the world. About 30% of the people that are affected by stroke die within a year; 25% of the patients that survive stroke remain in need of care after a year. Therefore, stroke is a major burden for health care costs. The most commo...

journal_title：Current stem cell research & therapy

authors： Zents K,Copray S

更新日期：2016-01-01 00:00:00

abstract：:Human mesenchymal stem cells (hMSCs) are multipotent non-hematopoietic precursor cells with the ability to differentiate into several tissue types. The use of hMSCs has gained significant importance in cancer therapies as well as a large number of degenerative disease therapies due to their homing abilities. However, ...

journal_title：Current stem cell research & therapy

authors： Serakinci N,Kalkan R,Tulay P

更新日期：2016-01-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) have the self-renewal ability and the ability to produce multiple differentiation. Elucidating the genetic circuits that govern MSC self-renewal and differentiation is necessary to improve our comprehension of MSCs and their role in regenerative medicine. microRNAs (miRNAs) play important...

journal_title：Current stem cell research & therapy

authors： Huang C,Gou S,Wang L,Huang K,Liu L,Zhao W,Zheng L,Xiao J

更新日期：2016-01-01 00:00:00

abstract：:Connections between inflammation and cancer are a rapidly developing field. Some gastrointestinal tract cancers arise from infection, chronic irritation, and ensuing inflammation. Cellular effectors and mediators are important constituents of the tumor microenvironment, including neoplastic, stromal, and migratory hem...

journal_title：Current stem cell research & therapy

authors： Zhang L,Song X,Mohri Y,Qiao L

更新日期：2015-01-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are ideal candidates for different cellular therapies due to their simple isolation, extensive expansion potential, and low immunogenicity. For various therapeutic approaches, such as bone and cartilage repair, MSCs are expected to replace the damaged tissues by direct differentiation. Ho...

journal_title：Current stem cell research & therapy

authors： Kuang W,Xu X,Lin J,Cao Y,Xu Y,Chen L,Jin L,Tan J

更新日期：2015-01-01 00:00:00

abstract：:Intervertebral disc (IVD) disorders, especially degenerative disc disease, reduce the quality of life, and are short of effective therapy. A new direction for treatment of chronic tissue and organ diseases is to promote regeneration by harnessing endogenous repair mechanisms. In this review, we discuss the potential o...

journal_title：Current stem cell research & therapy

authors： Li Z,Peroglio M,Alini M,Grad S

更新日期：2015-01-01 00:00:00

abstract：:Tendon and ligament injuries are common, and repair slowly with reduced biomechanical properties. With increasing financial demands on the health service and patients to recover from tendon and ligament injuries faster, and with less morbidity, health professionals are exploring new treatment options. Tissue engineeri...

journal_title：Current stem cell research & therapy

authors： Dhinsa BS,Mahapatra AN,Khan WS

更新日期：2015-01-01 00:00:00

abstract：:Osteoarthritis (OA) is the most common degenerative joint disorder worldwide. OA represents an increasing threat to the quality of life of affected persons as well as for health resources expenditure. The incapability of cartilage to heal has been long time regarded as the major cause of progressive joint degeneration...

journal_title：Current stem cell research & therapy

authors： Labusca L,Mashayekhi K

更新日期：2015-01-01 00:00:00

abstract：:Postnatal skeletogenesis is a highly regulated process that subpopulations of bone marrow stem cells differentiate into mature skeletal tissues to maintain and repair the postnatal skeletons. Based on their skeletogenic capacity, purified bone marrow stem cells have been used to repair and replace damaged skeletal tis...

journal_title：Current stem cell research & therapy

authors： Deng P,Xu X,Chen Q

更新日期：2015-01-01 00:00:00

abstract：:Despite the numerous recent advances made in conventional anticancer therapies, metastasis and recurrence still remain the major problems in cancer management. The current treatment modalities kill the bulk of the tumor, leaving cancer stem cells behind and therefore, the agents specifically targeting this cancer init...

journal_title：Current stem cell research & therapy

authors： Sak K,Everaus H

更新日期：2015-01-01 00:00:00

abstract：:Pluripotent stem cells (PSCs) derived from somatic cells represent a powerful experimental tool for investigating the molecular mechanisms underlying the disease phenotype; with prospects to advance medical therapies. They also have significant potential as a renewable source of autologous cells for cellular therapy. ...

journal_title：Current stem cell research & therapy

authors： Alateeq S,Fortuna PR,Wolvetang E

更新日期：2015-01-01 00:00:00

abstract：AIMS:A systematic review and meta-analysis were performed to explore the clinical outcome of the transplantation of stem cells from various human tissue sources in cirrhotic patients. METHODS:The relevant papers were searched via PubMed, EMBASE, and Cochrane Library databases. Changes in liver function before and afte...

journal_title：Current stem cell research & therapy

authors： Qi X,Guo X,Su C

更新日期：2015-01-01 00:00:00

abstract：:Intervertebral disc (IVD) degeneration is one of the leading causes of low back pain, which affects a large proportion of the global population at a huge socioeconomic burden. Current treatments focus primarily on symptomatic pain relief or surgery, but offer relatively poor long-term efficacy as they fail to address ...

journal_title：Current stem cell research & therapy

authors： Clarke LE,Richardson SM,Hoyland JA

更新日期：2015-01-01 00:00:00

abstract：:Neural stem cells (NSCs) are a small subset of primitive precursors that generate and maintain the main phenotypes of the nervous system. Their ability to undergo long-term proliferation and neural differentiation endows them with great potential in regenerative medicine. Therefore, the mechanisms by which NSCs are re...

journal_title：Current stem cell research & therapy

authors： Wang S,Xu J,Ye R,Wang J,Chen Z,Huang R,Peng Q,Xu Y,Cai X

更新日期：2014-05-01 00:00:00

abstract：:Although the existence of cancer stem cells (CSCs) has been demonstrated in colorectal cancer, further investigation is hindered by controversies over their surface markers. The sphere formation assay is widely used as in vitro method for derivation and characterization of CSCs based on the intrinsic self-renewal prop...

journal_title：Current stem cell research & therapy

authors： Wu H,Zhang H,Hu Y,Xia Q,Liu C,Li Y,Yu B,Gu T,Zhang X,Yu X,Kong W

更新日期：2014-03-01 00:00:00

abstract：INTRODUCTION:Retinitis pigmentosa (RP), an inherited disease characterized by progressive loss of photoreceptors and retinal pigment epithelium, is a leading genetic cause of blindness. Cell transplantation to replace lost photoreceptors is a potential therapeutic strategy, but technical limitations have prevented clin...

journal_title：Current stem cell research & therapy

authors： Peng Y,Zhang Y,Huang B,Luo Y,Zhang M,Li K,Li W,Wen W,Tang S

更新日期：2014-03-01 00:00:00

abstract：:Protein kinases (PKs) mediate the reversible conversion of substrate proteins to phosphorylated forms, a key process in controlling intracellular signaling transduction cascades. Pluripotency is, among others, characterized by specifically expressed PKs forming a highly interconnected regulatory network that culminate...

journal_title：Current stem cell research & therapy

authors： Shoni M,Lui KO,Vavvas DG,Muto MG,Berkowitz RS,Vlahos N,Ng SW

更新日期：2014-01-01 00:00:00

abstract：:Stem and progenitor cell research is a complex and exciting field which promises curative discoveries in numerous areas including cancer, diabetes, and regenerative medicine. Use of biotic factors or growth factors has played an essential role in the development of stem cell research. These biologically active compone...

journal_title：Current stem cell research & therapy

authors： Baadhe RR,Mekala NK,Potumarthi R

更新日期：2014-01-01 00:00:00

abstract：:Liver is a major metabolic organ of the body and is known to comprise of two epithelial cell lineages, namely, hepatocytes and cholangiocytes which are known to originate from hepatoblasts during fetal developing stages. Upon acute injury, the hepatocytes and cholangiocytes undergo cellular division to compensate the ...

journal_title：Current stem cell research & therapy

authors： Rehman K,Iqbal MJ,Zahra N,Akash MS

更新日期：2014-01-01 00:00:00

abstract：:Rotator cuff tear causes a high rate of morbidity. After surgical repair, the presence of a scar tissue reduces tendon biomechanical properties. Emerging strategies for enhancing tendon healing are growth factors, cytokines, gene therapy and tissue engineering. However their efficacy has to be proved. Growth factors h...

journal_title：Current stem cell research & therapy

authors： Longo UG,Rizzello G,Berton A,Maltese L,Fumo C,Khan WS,Denaro V

更新日期：2013-11-01 00:00:00

abstract：:Due to the nature of articular cartilage of being poorly vascularized the capabilities of self repair are limited. Mesenchymal stem cells transplantation is a modern technique which has been developed after the high success rates obtained by microfracturing and drilling techniques which promote the release of growth f...

journal_title：Current stem cell research & therapy

authors： Martinelli N,Bonifacini C,Longo UG,Marinozzi A,Florio P,Khan WS,Denaro V

更新日期：2013-05-01 00:00:00

abstract：:Human hepatocyte transplantation is being trialled in lieu of orthotopic liver transplants for patients with acute and chronic liver diseases. Stem cells that can be differentiated into hepatocyte-like cells may replace human hepatocytes that are difficult to source, culture and in critically short supply. Hepatocyte-...

journal_title：Current stem cell research & therapy

authors： Vaghjiani V,Vaithilingam V,Tuch B,Sievert W,Manuelpillai U

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Stem cell culture for regenerative medicine needs platelet rich plasma (PRP) as fetal bovine/calf serum (FBS/FCS) substitute. However, the various studies used various protocols in preparing and processing the PRP. This study aimed to compare and conclude the most effective and efficient protocol. METHODS:w...

journal_title：Current stem cell research & therapy

authors： Pawitan JA

更新日期：2012-09-01 00:00:00

abstract：:Conditions affecting cartilage through damage or age-related degeneration pose significant challenges to individual patients and their healthcare systems. The disease burden will rise in the future as life expectancy increases. This has resulted in vigorous efforts to develop novel therapies to meet current and future...

journal_title：Current stem cell research & therapy

authors： Mabvuure N,Hindocha S,Jordan D,Khan WS

更新日期：2012-07-01 00:00:00

abstract：:Treatment of metastatic melanoma is a challenge for clinicians as most agents have failed to demonstrate improved survival in phase III trials. Despite the immunogenicity of this tumor entity, different immunological interventions including cytokine therapy, vaccination, biochemotherapy or allogeneic hematopoietic cel...

journal_title：Current stem cell research & therapy

authors： Zeiser R,Schnitzler M,Andrlova H,Hellige T,Meiss F

更新日期：2012-05-01 00:00:00

abstract：:Due to the advent of less-toxic reduced intensity conditioning regimens (RIT), allogeneic hematopoietic cell transplantation (allo-HCT) is currently widely used to treat chemotherapy-resistant hematological diseases, particularly in older patients,which are the fastest growing group of patients receiving allo-HCT. How...

journal_title：Current stem cell research & therapy

authors： Toubai T,Tanaka J,Paczesny S,Shono Y,Reddy P,Imamura M

更新日期：2012-05-01 00:00:00

abstract：:Mesenchymal stem cells are multipotent stromal cells residing within the connective tissue of most organs. Their surface phenotype has been well described. Most commonly, mesenchymal stem cells demonstrate the ability to differentiate into mesenchymal tissues (bone, catailge, fat, etc...), however, under the proper co...

journal_title：Current stem cell research & therapy

authors： Grange S

更新日期：2012-03-01 00:00:00

abstract：:Recent studies have shown that treatments involving injection of stem cells into animals with damaged cardiac tissue result in improved cardiac functionality. Clinical trials have reported conflicting results concerning the recellularization of post-infarct collagen scars. No clear mechanism has so far emerged to full...

journal_title：Current stem cell research & therapy

authors： Li SC,Acevedo J,Wang L,Jiang H,Luo J,Pestell RG,Loudon WG,Chang AC

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Acute renal failure (ARF) resulting from ischemic or toxic insults remains a major health care problem because of its grave prognosis and the limited effectiveness of available treatment modalities. Current treatment options for ARF are limited to supportive measures and preventive strategies, none of which ...

journal_title：Current stem cell research & therapy

authors： Mohamed MI,Attia FM,Atwa KA

更新日期：2011-12-01 00:00:00

abstract：:Spinal cord injury (SCI) is a traumatic disorder resulting in a functional deficit that usually leads to severe and permanent paralysis. After the initial insult to the spinal cord, additional structure and function are lost through an active and complex secondary process. Since there is not effective treatment for SC...

journal_title：Current stem cell research & therapy

authors： Hernández J,Torres-Espín A,Navarro X

更新日期：2011-09-01 00:00:00

abstract：:Notch signaling mediates the fates of numerous cells in both invertebrates and vertebrates. In the immune system, Notch signalling contributes to the generation of hematopoietic stem cells (HSCs), the promotion of HSC self-renewal, T lineage commitment, intrathymic T cell development, and peripheral lymphocyte differe...

journal_title：Current stem cell research & therapy

authors： Nagase H,Koh CS,Nakayama K

更新日期：2011-06-01 00:00:00

abstract：:Type 1 diabetes mellitus is an autoimmune disease against pancreatic β cells. The autoimmune response begins months or years before the clinical presentation. At the time of hyperglycemic symptoms a small amount of β cell mass still remains. The main therapeutic option to type 1 diabetes mellitus is daily insulin inje...

journal_title：Current stem cell research & therapy

authors： Couri CE,Voltarelli JC

更新日期：2011-03-01 00:00:00

abstract：:Umbilical cord blood (UCB) is an alternative source of hematopoietic progenitors for transplantation in the treatment of haematological malignancies, marrow failure, immunodeficiencies, hemoglobinopathies and inherited metabolic diseases. It has greatly contributed to increase the feasibility to transplantation for ma...

journal_title：Current stem cell research & therapy

authors： Solves P,Mirabet V,Roig R

更新日期：2010-12-01 00:00:00

abstract：:About 30 years ago circulating endothelial cells (CEC) were first observed in peripheral blood. Since then CEC have been established as a reliable indicator of vascular injury and damage and more sophisticated detection techniques, such as immunomagnetic isolation and fluorescence-activated cell sorting (FACS), have b...

journal_title：Current stem cell research & therapy

authors： Erdbruegger U,Dhaygude A,Haubitz M,Woywodt A

更新日期：2010-12-01 00:00:00

abstract：:The pressing demand to elucidate the biology of human embryonic stem (ES) cells and to realize their therapeutic potential has greatly promoted the progresses in the optimization of the culture systems used for this highly promising cell type. These progresses include the characterization of exogenous regulators of pl...

journal_title：Current stem cell research & therapy

authors： Lin G,Xu RH

更新日期：2010-09-01 00:00:00

abstract：:During the past several years, mesenchymal stem cells (MSCs) derived from adult tissue have rapidly moved from in vitro and animal studies into clinical trials as a therapeutic modality for a diverse group of clinical applications, including head and neck reconstruction. For many diseases, cell therapy could affect th...

journal_title：Current stem cell research & therapy

authors： Hanson S,Thibeault SL,Hematti P

更新日期：2010-09-01 00:00:00

abstract：:Stem cells have been long looked at as possible therapeutic vehicles for different health related problems. Among the different existing stem cell populations, Adipose- derived Stem Cells (ASCs) have been gathering attention in the last 10 years. When compared to other stem cells populations and sources, ASCs can be e...

journal_title：Current stem cell research & therapy

authors： Salgado AJ,Reis RL,Sousa NJ,Gimble JM

更新日期：2010-06-01 00:00:00

abstract：:Tendon, the crucial element of the musculoskeletal system, when damaged, never restores the biological and biomechanical properties completely. Recently, tissue engineering and regenerative medicine have enabled the differentiation of postnatal somatic stem cells or mesenchymal stem cells (MSCs) to different cell line...

journal_title：Current stem cell research & therapy

authors： Uysal AC,Mizuno H

更新日期：2010-06-01 00:00:00

abstract：:Sarcomas are the mesenchymal-derived malignant tumors of connective tissues (e.g., fat, bone, and cartilage) presumed to arise from aberrant development or differentiation of mesenchymal stem cells (MSCs). Appropriate control of stem cell maintenance versus differentiation allows for normal connective tissue developme...

journal_title：Current stem cell research & therapy

authors： Siddiqi S,Mills J,Matushansky I

更新日期：2010-03-01 00:00:00